Journal of Experimental & Clinical Medicine
Volume 2, Issue 3 , Pages 111-117, June 2010

Dental Stem Cells and Tooth Banking for Regenerative Medicine

  • Yen-Hua Huang

      Affiliations

    • Department of Biochemistry, Graduate Institute of Medical Sciences, School of Medicine; Center for Reproductive, Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan
    • Center for Teeth Bank and Dental Stem Cell Technology, Taipei Medical University, Taipei, Taiwan
    • ,
  • Jen-Chang Yang

      Affiliations

    • School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • Center for Teeth Bank and Dental Stem Cell Technology, Taipei Medical University, Taipei, Taiwan
    • ,
  • Chin-Wei Wang

      Affiliations

    • Department of Dentistry, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan
    • School of Dentistry, Taipei Medical University, Taipei, Taiwan
    • ,
  • Sheng-Yang Lee

      Affiliations

    • Department of Dentistry, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan
    • School of Dentistry, Taipei Medical University, Taipei, Taiwan
    • Center for Teeth Bank and Dental Stem Cell Technology, Taipei Medical University, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author. School of Dentistry, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan

Received 23 September 2009; received in revised form 5 March 2010; accepted 12 March 2010.

Abstract 

Stem cell (SC) therapy has a promising future for tissue regenerative medicine. However, because SC technology is still in its infancy, interdisciplinary cooperation is needed to achieve successful clinical applications. Dental SCs have drawn attention in recent years because of their accessibility, plasticity, and high proliferative ability. Several types of dental SCs have been identified, including dental pulp SCs from adult human dental pulp, SCs from human primary exfoliated deciduous teeth, periodontal ligament SCs, and dental follicle SCs from human third molars. Similar to mesenchymal SCs, these dental SCs can undergo self-renewal and have multipotent differentiation ability, but do not have the ethical issues associated with other sources of SCs. Therefore, appropriate preservation procedures for dental SCs and teeth are now needed. Here, we discuss the opportunities for tooth-banking (as it is now clinically feasible and commercially available), the advantages and limitations of current cryopreservation techniques for dental SCs/teeth or tissues, and the current status of tooth banks.

Key Words:  cryopreservation , dental stem cell , stem cell therapy , tooth bank

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PII: S1878-3317(10)60018-6

doi:10.1016/S1878-3317(10)60018-6

Journal of Experimental & Clinical Medicine
Volume 2, Issue 3 , Pages 111-117, June 2010

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